2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-178251S
    L-Phenylalanine-d 55836-70-9
    L-Phenylalanine-d is the deuterium labeled L-Phenylalanine (HY-N0215). L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-d
  • HY-178385S
    Heneicosanoic acid-d3
    Heneicosanoic acid-d3 is the deuterium labeled Heneicosanoic acid (HY-121447). Heneicosanoic acid is a long-chain saturated fatty acid which is found in plants and animals.
    Heneicosanoic acid-d3
  • HY-178409S
    Ethyl nonanoate-d17
    Ethyl nonanoate-d17 is the deuterium labeled Ethyl nonanoate (HY-129623). Ethyl nonanoate is a rich ester in spirits and its presence is commonly related to the pleasant fruity bouquet of alcoholic beverages. Ethyl nonanoate is an endogenous metabolite.
    Ethyl nonanoate-d17
  • HY-178413S
    D-Mannitol-d4
    D-Mannitol-d4 (Mannitol-d4) is the deuterium labeled D-Mannitol (HY-N0378). D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed.
    D-Mannitol-d4
  • HY-178422S
    Heneicosanoic acid-d41
    Heneicosanoic acid-d41 is the deuterium labeled Heneicosanoic acid (HY-121447). Heneicosanoic acid is a long-chain saturated fatty acid which is found in plants and animals.
    Heneicosanoic acid-d41
  • HY-179170S
    Malonyl CoA-13C3 lithium 98%
    Malonyl CoA-13C3 (Malonyl coenzyme A-13C3) lithium is the 13C-labeled Malonyl CoA lithium (HY-136408). Malonyl CoA (Malonyl Coenzyme A) lithium is an inhibitor of carnitine palmitoyl transferase 1 (CPT1). High Malonyl CoA lithium concentrations suppress fatty acid oxidation, while low Malonyl CoA lithium concentrations are permissive for fat oxidation.
    Malonyl CoA-13C3 lithium
  • HY-179884S
    (E/Z)-12-OAHSA-d17 2749984-52-7
    (E/Z)-12-OAHSA-d17 is a deuterated endogenous lipid that belongs to branched fatty acid esters of hydroxy fatty acids (FAHFAs)
    (E/Z)-12-OAHSA-d17
  • HY-179905S
    (E/Z)-5-POHSA-d14 2749982-66-7
    (E/Z)-5-POHSA-d14 is a deuterated endogenous lipid that belongs to branched fatty acid esters of hydroxy fatty acids (FAHFAs)
    (E/Z)-5-POHSA-d14
  • HY-179968S
    1-Myristoyl-2-docosahexaenoyl-sn-glycero-3-phosphatidylcholine-d9 2770869-29-7 98%
    1-Myristoyl-2-docosahexaenoyl-sn-glycero-3-phosphatidylcholine-d9 is a deuterated phosphatidylcholine.
    1-Myristoyl-2-docosahexaenoyl-sn-glycero-3-phosphatidylcholine-d9
  • HY-179982S
    1-Oleoyl-2-linolenoyl-3-chloropropanediol-d5 2489624-01-1 98%
    1-Oleoyl-2-linolenoyl-3-chloropropanediol-d5 is a deuterated 3-monochloropropanediol (3-MCPD) glycidyl ester.
    1-Oleoyl-2-linolenoyl-3-chloropropanediol-d5
  • HY-181565A
    CDK7-IN-33 maleate 98%
    CDK7-IN-33 maleate is an orally active pyrimidine derivative and also a CDK7 kinase inhibitor. CDK7-IN-33 maleate is applicable to the research of cancer, inflammation, cardiovascular diseases, infectious diseases, immune diseases and metabolic diseases.
    CDK7-IN-33 maleate
  • HY-182094A
    DSPE-PEG2000-KTP
    DSPE-PEG2000-KTP is a PEG compound which composed of DSPE and a Kidney-targeting peptide KTP (HY-P11069). KTP can interact with specific proteins on the surface of renal tubular epithelial cells or exhibit higher affinity in the specific renal microenvironment, tending to aggregate or be internalized within the renal tubular epithelium. DSPE-PEG2000-KTP can actively guide carriers such as nanomedicines, liposomes, and microspheres to the kidney.
    DSPE-PEG2000-KTP
  • HY-182094B
    DSPE-PEG3400-KTP
    DSPE-PEG3400-KTP is a PEG compound which composed of DSPE and a Kidney-targeting peptide KTP (HY-P11069). KTP can interact with specific proteins on the surface of renal tubular epithelial cells or exhibit higher affinity in the specific renal microenvironment, tending to aggregate or be internalized within the renal tubular epithelium. DSPE-PEG3400-KTP can actively guide carriers such as nanomedicines, liposomes, and microspheres to the kidney.
    DSPE-PEG3400-KTP
  • HY-182094C
    DSPE-PEG5000-KTP
    DSPE-PEG5000-KTP is a PEG compound which composed of DSPE and a Kidney-targeting peptide KTP (HY-P11069). KTP can interact with specific proteins on the surface of renal tubular epithelial cells or exhibit higher affinity in the specific renal microenvironment, tending to aggregate or be internalized within the renal tubular epithelium. DSPE-PEG5000-KTP can actively guide carriers such as nanomedicines, liposomes, and microspheres to the kidney.
    DSPE-PEG5000-KTP
  • HY-18260S3
    Bisphenol A-d8 92739-58-7 99.26%
    Bisphenol A-d8 is the deuterium labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders.
    Bisphenol A-d8
  • HY-18260S5
    Bisphenol A-d4-1 347841-41-2 98%
    Bisphenol A-d4-1 is the deuterium labeled Bisphenol A. Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders.
    Bisphenol A-d4-1
  • HY-185229B
    rel-CTR/AMYR agonist-1 3108096-13-2
    rel-CTR/AMYR agonist-1 (Example 169) is an agonist of amylin and/or calcitonin receptor.
    rel-CTR/AMYR agonist-1
  • HY-185234A
    (R)-CTR/AMYR activator-1 3068778-30-0 98%
    (R)-CTR/AMYR activator-1 (Compound 122) is a CTR/AMYR activator with EC50 values of 0.8 and 0.73 nM. (R)-CTR/AMYR activator-1 can used for the researches of bone diseases, metabolic diseases, cardiovascular diseases, and neurodegenerative diseases.
    (R)-CTR/AMYR activator-1
  • HY-186121A
    Glucosylceramide synthase-IN-6 3118501-71-3 98%
    Glucosylceramide synthase-IN-6 (G3-3B) is a glucosylceramide synthase (GCS) inhibitor that can be used for the study of the diseases and disorders associated with GCS activity, such as lysosomal storage disorders.
    Glucosylceramide synthase-IN-6
  • HY-19657S1
    Oxypurinol-13C3,15N3
    Oxypurinol-13C3,15N3 (Oxipurinol-13C3,15N3) is the 13C- and 15N-labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
    Oxypurinol-13C3,15N3
Cat. No. Product Name / Synonyms Application Reactivity